Fig 3.
Covariation analysis of selected mutations in the LLRHHNMVY2450-2458 epitope. For each position (2421 to 2520) of the polyprotein (residues 1 to 100 in NS5B), a P value was calculated for the association between sequence polymorphisms and the presence of escape mutations inside the epitope. (A) Association between the escape mutation H2454R and polymorphisms at other sites. A significant association at position K2440 is marked with an arrow. (B) Association between the escape mutation M2456L and polymorphisms at other sites. A significant association at position K2439 is marked with an arrow. The epitope regions of both HLA B*15-restricted epitopes are indicated with boxes.