Table 1.
Susceptibility of HIV-1 NL4-3 variants with mutations in the GIV motif and in the pocket-forming region of the HIV-1 gp41 NHR domain to peptide HIV fusion inhibitorsa
| Virus | T20 |
C34 |
CP32 M |
C52L |
||||
|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | Resistance (n-fold) | IC50 (nM) | Resistance (n-fold) | IC50 (nM) | Resistance (n-fold) | IC50 (nM) | Resistance (n-fold) | |
| WT | 13.6 ± 0.39 | 1.0 | 2.2 ± 0.23 | 1.0 | 4.5 ± 0.37 | 1.0 | 8.2 ± 1.3 | 1.0 |
| V38E/N42S | 1,165.9 ± 80.5 | 85.7 | 9.24 ± 1.1 | 4.2 | 6.2 ± 0.72 | 1.3 | 13.0 ± 2.1 | 1.5 |
| Q64A | 22.6 ± 4.21 | 1.6 | 123.6 ± 10.6 | 56.2 | 35.6 ± 3.50 | 8.0 | 15.3 ± 3.4 | 1.8 |
| Q64L | 30.2 ± 0.52 | 2.2 | 220.6 ± 21.4 | 100.3 | 278.5 ± 5.61 | 62.1 | 20.1 ± 4.2 | 2.4 |
a
IC50 data represent means ± standard deviations.