Fig 1.

Study design and effect of CTLA-4 and IDO blockade on Kyn/Trp ratio. (A) Study design. Details are given in Materials and Methods. (B) IDO mRNA/18S rRNA ratio in the lymph nodes during ART only (week 32) and at 1 week from the second treatment. (C to E) Trp (C) and Kyn (D) levels and Kyn/Trp ratio (E) measured at 1 week after treatment with 1mT. Each animal is represented by a symbol, as indicated. In all graphs the thick lines represent the mean values among all animals at each time point.