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Surface view of the DENV-3 protease. (A) The surface of the DENV protease shows the binding site of the Bz-nKRR-H peptide (as sticks; left). (B) The reverse face of the molecule shows the allosteric pocket (indicated by a dotted oval) that is lined by residues from both NS2B (cyan) and NS3 (green) and can potentially be targeted by low-molecular-weight inhibitors. N152 and I165 are shown as sticks.
