Fig 6.

Detailed view of the catalytically competent geometry in the DENV-3 protease structures. (A) Stick representation of the oxyanion hole and catalytic triad (H51, D75, and S135) from the DENV-3 protease-Bz-nKRR-H structure. The catalytic-triad residues are in blue, and other residues are in green. Only the P1 and P2 residues are shown for clarity. The water and sulfate by the oxyanion hole are shown as a sphere and sticks, respectively. Potential hydrogen bonds (up to 3.2 Å) are indicated by the dashed lines. (B) Sticks representation of the oxyanion hole of the DENV-3 protease-aprotinin structure. The protease residues are colored as in panel A. The P1′ to P2 residues of aprotinin are shown as yellow sticks, and the carbonyl of the P1 residue occupies the oxyanion hole.