Fig 5.
Cyclosporine treatment and cyclophilin D knockdown protects human neurons from rOC/ATCC-induced programmed cell death. Wild-type LA-N-5 cells were treated with cyclosporine (CsA), and two LA-N-5 populations knocked down for CypD (pop K CypD-kd and pop M CypD-kd) were infected with rOC/ATCC or rOC/US183-241. Images represent phase-contrast microscopy pictures taken at 48 h postinfection. The control LA-N-5 empty cell population is not presented since these cells were comparable to nontreated CsA wild-type LA-N-5 cells. Arrows indicates dendrites and axons. Arrowheads indicate rounding and shrinking bodies.