Table 2.
Intrapatient dN/dS ratios of type 1 and type 2 HERV-K (HML-2) RNA sequences over three time points in plasma from HIV-1-positive patients
Patient | Type 1 |
Type 2 |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
No. of sequences | dN | dS | dN/dS ratio | P valuea | No. of sequences | dN | dS | dN/dS ratio | P valuea | |
1 | 27 | 0.0325 | 0.0730 | 0.44 | <0.001 | 3 | 0.0068 | 0.0424 | 0.16 | <0.001 |
2 | 30 | 0.0378 | 0.0606 | 0.62 | <0.001 | 6 | 0.0975 | 0.1494 | 0.65 | <0.001 |
3 | 40 | 0.0318 | 0.0618 | 0.51 | <0.001 | 22 | 0.0920 | 0.1977 | 0.46 | <0.001 |
4 | 27 | 0.0461 | 0.1180 | 0.39 | <0.001 | 34 | 0.1104 | 0.1684 | 0.65 | <0.001 |
5 | 28 | 0.0371 | 0.0651 | 0.56 | <0.001 | 33 | 0.0768 | 0.1511 | 0.50 | <0.001 |
6 | 31 | 0.0548 | 0.0964 | 0.56 | <0.001 | 17 | 0.0819 | 0.1960 | 0.41 | <0.001 |
Statistical significance taken from the log likelihood Z test. P values reflect comparisons of the dN/dS ratios obtained in this study to the null hypothesis (dN/dS = 1).