Table 3.
Conservation of viral HLA ligands in several orthopoxvirusesa
| Poxvirus | A17L9-17 (HLA-A2) | A10L614-623 (HLA-A2) | A10L688-696 (HLA-A2) | A10L867-876 (HLA-B27) | B8R53-59 (HLA-B27) | K2L16-30 (HLA-B27, -Cw1) | D5R148-157 (HLA-B51) | A50R294-301 (HLA-B51) | C11R101-110 (HLA-B51, -Cw1) | A17L9-25 (HLA-Cw1) | D8L112-119 (HLA-Cw1) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| VACV WR | MLDDFSAGA | SPEGEETII | ILDRIITNA | SRGYFEHMKK | WQTMYTN | YRLQGFTNAGIVAYK | IAMKRTLLEL | LPFGSLGI | IPSPGIMLV | MLDDFSAGAGVLDKDL | DGLIIISI |
| VACV Copenhagen | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | --------- | ---------------- | -------- |
| VACV MVA | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | --------- | ---------------- | -------- |
| Variola major | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | -------- |
| Variola minor | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | -------- |
| Camelpox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | -------- |
| Cowpox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | --I--VA- |
| Ectromelia virus | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | --------- | ---------------- | -------- |
| Horsepox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | --------- | ---------------- | -------- |
| Monkeypox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ---L--V-- | ---------------- | --I---A- |
| Rabbitpox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | -------- |
| Taterapox | --------- | --------- | --------- | ---------- | ------- | --------------- | ---------- | -------- | ------V-- | ---------------- | -------- |
a
The sequences used were obtained from the NCBI database (http://blast.ncbi.nlm.nih.gov/Blast.cgi).