Fig 7.

A schematic illustration showing the interactions of baculovirus with its target molecules on the cell surface. (A) Baculovirus binds to heparan sulfate and is being endocytosed. (B) Heparin-binding peptide binds to heparan sulfate on the cell surface, blocking the virus interaction with heparan sulfate. (C) Baculovirus binds to the receptor through its receptor binding domain and is being endocytosed. (D) Heparin binds to the heparin-binding region on gp64 and prevents virus binding to heparan sulfate. On the surface of Sf9 cells, blocking the interaction with heparan sulfate will not inhibit virus entry, since baculovirus can still bind to its specific receptor as shown in panel C.