Fig 5.

VACs significantly reduce virus-induced toxicity. (A) Serum cytokine levels. IL-6 and IL-12 (p70) were assessed 6 h after systemic administration of a single dose of either virus alone (1 × 10¹¹ virus particles), the same dose of virus mixed with different amounts of anti-adenovirus antibody, or saline (PBS). (B) Platelets. Fourteen days before treatment, baseline platelet counts were determined (t = 0). A notable drop in platelet count was observed only in animals given virus alone. (C) Kinetic profile of serum alanine aminotransferase (ALT). Normal levels for C57BL/6 mice fall within the range of 24 to 140 U/liter (40). (D) Kinetic profile of serum aspartate aminotransferase (AST). Normal levels for C57BL/6 mice fall within the range of 72 to 288 U/liter (40). In each panel, data reflect average values ± the standard error of the mean for 5 mice from each treatment group. Statistical significance was determined between individual treatment groups and vehicle controls by one-way analysis of variance with a Bonferroni/Dunn post hoc test. *, P ≤ 0.05; **, P ≤ 0.01.