Table 1.
Infectious titer as determined by two in vitro assays for each production lot of virus-antibody complexesa
| Treatment | ITA (ivp/ml) | PLA (PFU/ml) | PFU:IVP ratio |
|---|---|---|---|
| Adenovirus alone | 4.08 ± 0.22 × 1010 | 4.5 ± 0.48 × 1010 | 1:1.1 |
| Virus + 500 ND50 | 1.02 ± 0.52 × 108 | 3.2 ± 0.95 × 106 | 1:32 |
| Virus + 5 ND50 | 1.60 ± 0.55 × 108 | 3.6 ± 0.28 × 106 | 1:44 |
| Virus + 0.05 ND50 | 2.30 ± 0.92 × 108 | 4.2 ± 0.73 × 106 | 1:55 |
| Virus + 0.005 ND50 | 2.53 ± 0.22 × 1010 | NA | |
| Virus + 0.0005 ND50 | 3.62 ± 0.15 × 1010 | NA |
a
The input for each of these preparations was 1.0 × 1011 virus particles/ml, as determined by measuring the absorbance of each preparation at 260 nm. ITA, infectious titer assay; ivp, infectious virus particles; PLA, plaque assay; NA, not assayed.