Table 1.

Probability of GHD by Mean Dose to the Hypothalamus and Time After Irradiation Using Peak GH Data Through 36 and 60 Months After Conformal RT

Time After RT Start (months)	Mean Dose to Hypothalamus (Gy)	36-Month Data (GH, ng/mL)*			60-Month Data (GH, ng/mL)†
		Probability of < 7	Probability of < 3	Predicted Mean Peak	Probability of < 7	Probability of < 3	Predicted Mean Peak
12	5	0.15	0.0093	13.55	0.16	0.0107	13.07
	10	0.18	0.0120	12.73	0.18	0.0130	12.46
	15	0.20	0.0154	11.96	0.20	0.0157	11.89
	20	0.23	0.0196	11.23	0.23	0.0189	11.34
	25	0.26	0.0247	10.55	0.25	0.0226	10.81
	30	0.29	0.0309	9.92	0.27	0.0269	10.31
	35	0.33	0.0383	9.32	0.30	0.0318	9.83
	40	0.36	0.0472	8.75	0.32	0.0375	9.38
	45	0.40	0.0576	8.22	0.35	0.0439	8.94
	50	0.44	0.0697	7.73	0.38	0.0513	8.53
	55	0.48	0.0837	7.26	0.41	0.0595	8.13
	60	0.52	0.0998	6.82	0.44	0.0688	7.76
36	5	0.19	0.0135	12.36	0.18	0.0131	12.44
	10	0.28	0.0274	10.25	0.25	0.0227	10.79
	15	0.38	0.0518	8.50	0.32	0.0377	9.36
	20	0.50	0.0910	7.05	0.41	0.0599	8.12
	25	0.61	0.1486	5.85	0.50	0.0912	7.04
	30	0.72	0.2267	4.85	0.58	0.1332	6.11
	35	0.81	0.3237	4.02	0.67	0.1869	5.30
	40	0.88	0.4346	3.33	0.74	0.2524	4.60
	45	0.93	0.5508	2.77	0.81	0.3282	3.99
	50	0.96	0.6628	2.29	0.86	0.4119	3.46
	55	0.98	0.7620	1.90	0.91	0.4998	3.00
	60	0.99	0.8426	1.58	0.94	0.5877	2.60
60	5	0.23	0.0193	11.28	0.21	0.0160	11.84
	10	0.40	0.0569	8.26	0.33	0.0379	9.34
	15	0.59	0.1369	6.04	0.47	0.0800	7.37
	20	0.76	0.2720	4.42	0.61	0.1504	5.82
	25	0.89	0.4526	3.24	0.75	0.2533	4.59
	30	0.95	0.6437	2.37	0.85	0.3844	3.62
	35	0.99	0.8039	1.74	0.92	0.5305	2.86
	40	1.00	0.9104	1.27	0.96	0.6725	2.25
	45	1.00	0.9664	0.93	0.98	0.7931	1.78
	50	1.00	0.9898	0.68	0.99	0.8825	1.40
	55	1.00	0.9975	0.50	1.00	0.9403	1.11
	60	1.00	0.9995	0.37	1.00	0.9731	0.87

Abbreviations: GH, growth hormone; GHD, growth hormone deficiency; RT, radiation therapy.

^*36-month model: peak GH = exp(2.6518 + {time × [0.001385 − (0.00104 × mean dose)]}).

^†60-month model: peak GH = exp(2.5947 + {time × [0.0019 − (0.00079 × mean dose)]}).