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. 2011 Oct 31;29(36):4803–4810. doi: 10.1200/JCO.2011.35.4928

Table 2.

Demographic and Clinical Characteristics of Genotype-Specific Subsets of Patients With Gastroesophageal Cancer

Characteristic MET (n = 10)
 EGFR (n = 23)
 HER2 (n = 45)
 Negative (n = 411)
 P
No. % No. % No. % No. % METv Negative EGFRv Negative HER2v Negative
Age, years .71 .71 .68
    Median 66 63 63 65
    Range 33-83 34-84 36-92 22-96
Sex 1.0 .14 .36
    Male 8 80 14 61 37 82 308 75
    Female 2 20 9 39 8 18 103 25
Site
    Esophageal 3 30 18 78 30 67 171 42
    Junctional 3 30 1 4 10 22 83 20
    Gastric 4 40 4 17 5 11 157 38
IM* .38 .78 < .001
    Prior positive 3 30 4 17 23 51 42 10
    Prior negative 4 40 15 65 17 38 118 29
    NA 3 30 4 17 5 11 251 61
Pathology .52 1.0 .75
    Adenocarcinoma 10 100 19 83 44 98 387 93
        Intestinal 8 80 18 78 41 92 303 74
        Diffuse 1 10 1 4 2 4 75 18
        Mixed 4 1
        Mucinous 1 10 4 1
        Medullary 1 2 1 0.2
    Adenosquamous 1 0.2
    Squamous 4 17 1 2 16 3.9
    Neuroendocrine 7 1.7
Differentiation .02 < .001 < .001
    Well 12 27 14 4
    Moderate 1 10 7 30 16 36 186 45
    Poor 9 90 16 70 17 38 206 50
    Undifferentiated 5 1
Stage† .04 .69 .04
    0 8 18 28 7
    I 1 10 4 17 6 13 58 14
    II 2 9 11 24 72 17
    III 2 20 7 30 6 13 106 26
    IV 7 70 10 43 14 31 147 36

NOTE. Negative indicates no MET/EGFR/HER2 amplification. P values from Fisher's exact test for dichotomous variables: intestinal versus diffuse cancer type; low-grade (well plus moderate) versus high-grade (poor plus undifferentiated) or c2 for stage comparisons (taking all categories into account).

Abbreviations: IM, intestinal metaplasia; NA, not applicable.

*

Samples with histologically confirmed IM, defined as Barrett's esophagus (esophageal or junctional samples) or chronic atrophic gastritis with IM (gastric samples) in at least one prior biopsy (ie, prior positive) were tallied versus patients with prior biopsies without evidence of IM (ie, prior negative); NA refers to patients without previous biopsies.

†

Staging including subcategories for esophageal and gastric lesions is provided in Fig 2; findings by anatomic location (esophageal v junctional v gastric) are tallied in the Data Supplement.