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Evolution of UL97 and pol mutations in strain T2294 under CPV. In each experiment (M89, M108, M111), exonuclease mutant strain T2294 was passaged under increasing concentrations of CPV and genotypes were determined periodically at the passage number shown on the bottom scale. The degree of CPV resistance (fold change in EC50 value) conferred by the mutations selected is shown in parentheses. wt, wild type.
