Fig 4.

CMV DNA polymerase catalytic region structure model. The Pol catalytic region contains palm and finger domains, as shown, and a thumb domain extending past residue 981 (data not shown). The structure is modeled on the published herpes simplex virus Pol structure (Protein Data Bank accessionr number 2gv9.pdb) using CPHmodels, version 3.0. Residues affecting CPV susceptibility are labeled; they are also involved in resistance to FOS with or without resistance to GCV/CDV. Mutation Q578H is located in a separate amino-terminal domain just left of residue 813 in this view.