Fig 3.

NS3 sequence and HCV RNA concentration dynamics in patients with multiple treatment-emergent substitutions. Clonal sequence analysis of a rebound (A), a plateau (B), and a continuous-decline (C) patient who carry more than one of the four treatment-emergent amino acid positions identified by population-based analysis. Pie charts represent NS3 sequence classes at each time point centered over the corresponding HCV load. “Baseline Majority” describes the baseline identity of amino acids that undergo treatment-emergent substitution in that patient. Unrelated, low-abundance sequences are grouped (other). Median danoprevir susceptibility of sequence variant classes is indicated as half-maximal effective concentration (EC₅₀) in a cell-based reporter assay where data were available.