Table 2.

Prominent treatment-emergent NS3 substitutions in individual patients identified through population-based sequencing

Virologic group	No. of patients with genotype		Sequence
	HCV 1a	HCV 1b
Rebound (n = 10)	8	1	R155K
		1	V71I/V, R155R/K/Q,c D168D/E, V170V/I
Plateau (n = 11)a		1	R155R/Kd
		1	I/V71I, R155R/Kd
		1	R155Q
		1	D168D/V
		1	D168T
		1	I/V71V
		1	V170I/V
		4	WTe
Decline (n = 4)b	1		R155K, I170I/V
	1	2	WT

^aSequence information could not be obtained from 2 plateau patients at EOT.

^bSequence information could not be obtained from 10 continuous-decline patients at EOT.

^cClonal sequence analysis confirmed a mixed population of R, K, and Q at position 155.

^dClonal sequence analysis indicated a mixed population of R and K at position 155.

^eWT, wild type.