Table 2.

Pharmacokinetics of tenofovir in macaques following intrarectal administration of 0.2%, 1%, and 5% tenofovir gel^a

Compartment and dose (%)	Cmax (μg/ml)	Tmax (h)	Clast (μg/ml)	AUC0–24 (μg · h/ml)
Vaginal fluid
0.2	18.22 ± 159.066	4.0 ± 2.934	2.61 ± 14.039	85.16 ± 203.622
1	37.93 ± 151.221	2.5 ± 9.020	9.11 ± 4.457	377.58 ± 615.747
5	196.650 ± 624.735	1.0 ± 9.338	108.45 ± 52.008	2,207.20 ± 1,008.223
Rectal fluid
0.2	2,644.62 ± 1,616.916	0.30 ± 0.306	2.17 ± 18.009	4,870.16 ± 3,976.541
1	6,614.20 ± 2,472.813	0.30 ± 0.306	11.28 ± 44.224	30,581.94 ± 27,528.478
5	12,094.96 ± 2,317.247	0.30 ± 0.387	45.09 ± 115.301	31,742.73 ± 57,633.168
Blood plasma
0.2	0.052 ± 0.0238	0.25 ± 0.387	0.001 ± 0.0006	0.121 ± 0.0667
1	0.278 ± 0.0870	0.25 ± 0.387	0.001 ± 0.0010	0.739 ± 0.2220
5	1.06 ± 0.513	1.00 ± 0.306	0.002 ± 0.0095	2.532 ± 1.151

^aValues are medians ± standard deviations. C_last, last concentration measured.