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Target attainment for suppression of emergence of resistance for cefepime plus tobramycina
| Tobramycin MIC (mg/liter) | Target attainment (% of 9,999 simulated subjects) |
|---|---|
| 0.25 | 100 |
| 0.5 | 100 |
| 1.0 | 70 |
| 2.0 | <1 |
| 4.0 | 0 |
Cefepime and tobramycin were administered at doses of 2 g every 8 h and 7 mg/kg/day, respectively. The rates of cefepime's target attainment for the 2-g-every-8-h dose are 100% at an MIC of 4 mg/liter and 99.5% at an MIC of 8 mg/liter.
