Table 2.

Univariate analysis of associations between exposure to different variables and 14-day mortality in 801 episodes of bloodstream infection

Variable	Mortality at 14 days (no. of deaths/no. of infections [%])	RR (95% CI)	P valuec
Gender
Male	96/473 (20.3)	Reference
Female	52/318 (15.9)	0.71 (0.57–1.06)	0.1
Age (yr)
≤55	25/204 (12.3)	Reference
>55	123/597 (20.6)	1.68 (1.13–2.51)	0.007
Type of acquisition
Community	22/149 (14.8)	Reference
Health care associated	34/192 (17.7)	1.20 (0.73–1.96)	0.4
Hospital	92/560 (20)	1.35 (0.88–2.08)	0.1
Type of hospital
Tertiary	112/637 (17.6)	Reference
Community	36 (164 (22.0)	1.25 (0.89–1.74)	0.1
Charlson index
0–1	42/334 (12.6)	Reference
2	41/212 (19.3)	1.54 (1.04–2.28)	0.03
≥3	65/255 (25.5)	2.03 (1.52–3.74)	<0.001
Neutropenia
No	133/755 (17.6)	Reference
Yes	15/46 (32.6)	1.85 (1.19–2.88)	0.01
Pitt score
0-1	47/491 (9.6)	Reference
2	15/92 (16.3)	1.70 (1.00–2.91)	0.05
≥3	86/218 (39.4)	4.12 (3.00–5.66)	<0.001
ICU admission
No	90/646 (13.9)	Reference	<0.001
Yes	58/155 (37.4)	2.69 (2.03–3.55)
Severity of SIRS at presentation
Sepsis	62/594 (10.4)	Reference
Severe sepsis	37/100 (37.0)	3.16 (2.19–4.56)	<0.001
Septic shock	53/107 (49.5)	4.75 (3.50–6.43)	<0.001
Sourcea
Low risk	36/352 (10.2)	Reference
High risk	112/449 (24.9)	2.44 (1.72–3.46)	<0.001
Etiologyb
Low risk	48/386 (24.1)	Reference
High risk	100/415 (24.1)	1.94 (1.41–2.66)	<0.001
Empirical therapy
Adequate	99/602 (16.4)	Reference
Inadequate	49/199 (24.6)	1.47 (1.10–2.02)	0.01

^aLow-risk sources include the biliary tract, urinary tract, and vascular catheter. For further explanation, see the text and Table 3.

^bLow-risk etiology includes monomicrobial episodes caused by Klebsiella spp., Escherichia coli, and coagulase-negative staphylococci. For further explanation, see the text and Table 3.

^cP values were calculated by the chi-square test.