Fig 1.

Pharmacokinetic profiles for the first dose-ranging hollow-fiber experiment (K. pneumoniae 27-908M and 4207J). Targeted (solid curves) and measured concentration-time profiles for ceftaroline (triangles) and NXL104 (squares) in hollow-fiber systems are shown. For experimental arms that received both drugs (arms E to H), the PK profiles for each drug are shown in separate graphs for clarity. Arms A and B are not shown because they were the nontreatment controls for K. pneumoniae 27-908M and 4207J. For experimental arms in which the bacterial strain is not stated, the KPC-2 β-lactamase-producing strain, K. pneumoniae 27-908M, was examined (i.e., arms E through I). CPT, ceftaroline.