Fig 5.

Second 10-day dose-ranging hollow-fiber study (HFS) using only K. pneumoniae strain 27-908M, the KPC-2-producing isolate. This strain also has the genes that encode TEM-1 and SHV-27 β-lactamases. The bacterial suspension was washed to remove preformed β-lactamases before it was inoculated into hollow-fiber systems. The effect of each regimen on the total bacterial population is shown. Experimental arms that had not failed (noted by outgrowth) by day 10 were continued to day 13 to better define the effect of their treatment regimens on microbiological outcomes. In this experiment, NXL104 was given as a continuous infusion.