Fig 7.

Dose fractionation study for NXL104 24-h AUC of 192 mg · h/liter in combination with a fixed regimen of ceftaroline at 600 mg q8h. The bacterium evaluated was K. pneumoniae 27-908M, the KPC-2 expression strain. The effect of each regimen on the total bacterial population is shown. For these experiments, the bacteria were washed to remove preformed β-lactamases prior to inoculating the bacteria into the hollow-fiber systems. Treatment arms that did not fail within 10 days of therapy were continued to day 13 to better delineate the effect of each regimen on microbiological outcomes. AUC, area under the concentration-time curve.