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Zinc acetate in HEC does not prevent vaginal or rectal HSV-2 infection in mice. Medroxyprogesterone acetate-treated (vaginal; A) or untreated (rectal; B) mice had the indicated gels (versus D-PBS or the zinc acetate solution) applied vaginally or rectally 10 min before being challenged with 106 PFU (via the respective routes). Survival was monitored for up to 20 days, and the survival curves are shown for each condition (n = 15 to 20 for each treatment group).
