Fig 2.

Final population pharmacokinetic model of caspofungin. (a and b) Observations versus population (a) or individual (b) predictions. The line of identity is shown. (c and d) Conditional weighted residuals versus population predictions (c) or time after dose (d). (e and f) Visual predictive check showing observations and model predictions on day 1 (e) and day 4 (f). The median (solid line) and the 5th and 95th percentiles (dashed black lines) for the observed data with 95% confidence intervals (gray fields) based on simulations are shown.