Table 2.
Summary of in vivo treatmentsa
| Compound(s) (in mg/kg) | No. of mice |
||
|---|---|---|---|
| dCM | dSM | Survived | |
| Control saline | 17 | 8 | 0 |
| Control DMSO | 13 | 4 | 0 |
| Chloroquine (1.7) | 3 | 3 | 0 |
| Chloroquine (5) | 4 | 2 | 0 |
| Chloroquine (15) | 7 | 5 | 0 |
| Mefloquine (0.33) | 8 | 1 | 0 |
| Mefloquine (1) | 8 | 1 | 0 |
| Mefloquine (2) | 7 | 2 | 0 |
| Mefloquine (3) | 5 | 1 | 0 |
| Piperaquine (2) | 4 | 3 | 0 |
| Piperaquine (6) | 3 | 5 | 0 |
| Piperaquine (10) | 0 | 7 | 1 |
| Piperaquine (18) | 2 | 4 | 2 |
| Artesunate (5) | 6 | 2 | 0 |
| Artesunate (10) | 3 | 5 | 0 |
| Artemisone (5) | 8 | 3 | 5 |
| Artemisone (10) | 4 | 3 | 8 |
| Artemiside (0.11) | 9 | 1 | 0 |
| Artemiside (0.33) | 3 | 6 | 0 |
| Artemiside (0.66) | 8 | 0 | 0 |
| Artemiside (1) | 3 | 1 | 4 |
| Artemiside (3) | 5 | 0 | 2 |
| Chloroquine (5) and artemisone (10) | 1 | 0 | 6 |
| Chloroquine (15) and artemisone (10) | 0 | 0 | 7 |
| Piperaquine (10) and artemisone (5) | 0 | 0 | 8 |
| Chloroquine (10) and artemiside (0.66) | 1 | 3 | 2 |
| Mefloquine (2) and artemiside (0.33) | 2 | 3 | 4 |
| Mefloquine (1) and artemiside (1) | 1 | 0 | 5 |
| Mefloquine (2) and artemiside (1) | 1 | 0 | 7 |
| Piperaquine (10) and artemiside (0.66) | 0 | 0 | 9 |
a
The table summarizes in vivo experiments in which mice were injected with P. berghei ANKA and treated with drugs alone or in combination with artemiside. Mice that died at a parasitemia below 20% with accompanying neurological symptoms, matching clinical score, and brain histology were considered to have died of CM (dCM). Mice which did not die of CM went on to die at higher parasitemias, with severe anemia (dSM).