Table 6.
Serum clinical chemistry evaluations after 4 repeat dose administrations in micea
| Compound | Dose (mg/kg) | Concn (IU/liter) |
Concn (mg/dl) |
Concn (U/liter) |
Cholesterol concn (mg/dl) | ||||
|---|---|---|---|---|---|---|---|---|---|
| SGPT | SGOT | ALP | Urea | Creatinine | LDH | CK-MB | |||
| Vehicle | 0 | 28 (7) | 71 (5) | 38 (2) | 29 (6) | 12 (2) | 630 (39) | 120 (12) | 124 (18) |
| PP-9 | 10 | 30 (6) | 65 (7) | 40 (3) | 30 (4) | 11 (1) | 620 (40) | 78 (9) | 115 (12) |
| PP-10 | 10 | 28 (4) | 72 (2) | 39 (4) | 31 (3) | 14 (0.678) | 625 (29) | 118 (11) | 128 (9) |
a
All compounds were administered orally. Values are means (standard deviations) of four animals. SGPT, serum glutamate pyruvate transaminase; SGOT, serum glutamate oxaloacetate transaminase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; CK-MB, creatine kinase.