Fig 9.

Summary of events following MG treatment of Candida cells, as evidenced by microarray profiling and TF screening. Categories of genes or processes that are upregulated are shown in green, while those downregulated are shown in red. MG treatment leads to a depletion of the LIP, a metabolic shift toward fermentation, and the downregulation of respiratory genes, which might cause the observed increase in ROS levels (indicated by dashed arrows), probably leading to cell necrosis. TF screening revealed that UPC2 and STP2 are MG responsive, showing convergence at MET6. Apart from these, other genes that are affected are involved in DNA repair, opaque/white switching, virulence, drug transport, etc.