Table 1.
PK/PD modeling results of the time course effects of PD-0162819 against H. influenzae 3113 in SCTK and chemostat systems
| Parameter | Unit | Value |
|
|---|---|---|---|
| Static concentration time-killa | Dynamic concentration time-killa | ||
| krep | h−1 | 2.04 ± 0.14 (1.8–2.3) | 1.80 ± 0.10 (1.6–2.0) |
| Nmax | CFU/ml | 108.80 ± 0.15 (108.6–109.0) | 109.28 ± 0.04 (109.2–109.3) |
| kkill | h−1 | 2.53 ± 0.14 (2.3–2.8) | 2.02 ± 0.11 (1.8–2.2) |
| EC50 | μg/ml | 0.0456 ± 0.0043 (0.039–0.053) | 0.340 ± 0.041 (0.27–0.41) |
| γ | 1.80 ± 0.15 (1.6–2.1) | 1.88 ± 0.42 (1.2–2.6) | |
| kglag | h−1 | 0.171 ± 0.065 (0.07–0.28) | |
| kdlag | h−1 | 1.91 ± 0.20 (1.6–2.2) | 3.06 ± 1.10 (1.2–4.9) |
| r2 | 0.91 | 0.98 | |
a
NONMEM estimate ± standard error (90% confidence intervals are shown in parentheses).