Fig 2.

Inhibition of galectin-induced erythrocyte hemagglutination by galactoside and lactoside derivatives. (A) Structures of the studied compounds. Compounds showing high preference for galectin-1, as shown in panels B and C, are marked with squares and were selected for further studies. (B) Compounds were evaluated for their ability to block the cell-cell aggregation of RBC mediated by galectins. Data shown represent the means of data for triplicate samples and are representative of three different experiments. Potencies of the compounds relative to that of lactose is shown. (C) The minimum inhibitory concentrations (mM) of some compounds are shown. Experiments were done twice, and representative data are shown in the table. For panels B and C, no SEM is shown due to minimal differences between triplicate samples.