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Pharmacodynamic data analysis according to the in vitro PK/PD model. Simulated human dosing with 1 mg/kg amphotericin B, 4 mg/kg voriconazole, or 1 mg/kg caspofungin was used against A. fumigatus, A. flavus, and A. terreus clinical isolates. The circles and squares represent galactomannan indices obtained in experiments without and with the drugs, respectively, while the lines represent the regression lines obtained with the Emax model.
