Table 2.
Pharmacodynamic parameters of simulated doses of amphotericin B, voriconazole, and caspofungin against A. fumigatus, A. flavus, and A. terreus isolates in the in vitro PK/PD model
| Drug (simulated dose [mg/kg]) and species | Mean Emaxa (GI) ± SD |
% Change | Mean T50b (h) ± SD |
|||
|---|---|---|---|---|---|---|
| With drug | Without drug | With drug | Without drug | Difference | ||
| Amphotericin Β (1) | ||||||
| A. fumigatus | 10.22 ± 0.65 | 0 | −100c | 5.3 ± 0.7 | >72 | >−66.7c |
| A. flavus | 11.54 ± 0.21 | 11.12 ± 0.26 | −3.6 | 7.5 ± 0.67 | 30.31 ± 4.24 | −22.8c |
| A. terreus | 10.72 ± 0.36 | 10.96 ± 1.73 | 2.2 | 4.45 ± 0.61 | 11.98 ± 2.84 | −7.53c |
| Voriconazole (4) | ||||||
| A. fumigatus | 11.29 ± 0.18 | 5.70 ± 0.03 | −49.5c | 14.81 ± 0.61 | 18.80 ± 0.25 | −3.99c |
| A. flavus | 11.35 ± 0.43 | 10.63 ± 0.14 | −6.3 | 7.13 ± 0.76 | 3.82 ± 0.09 | 3.31c |
| A. terreus | 12.02 ± 0.34 | 8.66 ± 0.29 | −27.9c | 10.92 ± 0.93 | 16.29 ± 1.33 | −5.37c |
| Caspofungin (1) | ||||||
| A. fumigatus | 9.24 ± 0.08 | 8.97 ± 0.08 | −2.9 | 8.28 ± 0.30 | 8.22 ± 0.07 | −0.02 |
| A. flavus | 9.38 ± 0.06 | 9.21 ± 0.04 | −1.8 | 3.26 ± 2.1 | 4.41 ± 0.45 | 1.15 |
| A. terreus | 9.27 ± 0.48 | 8.83 ± 0.06 | −4.7 | 7.68 ± 0.49 | 10.48 ± 0.52 | 2.8c |
a
Emax, maximum GI.
b
T50, time required to obtain 50% of Emax.
c
Statistically significantly different (P < 0.05).