Table 4. Top regions associated at P<10−5.
Top SNP | Alleles (A1/A2) | Chr | Pos | #SNPs at P<10−4 | Freq (A1) | OR (A1) | P | Nearest gene, description, relative SNP location |
rs11856574* | G/A | 15 | 27518736 | 1/13 | 0.86 | 2.02 | 5.0×10−6 | KIAA0574, hypothetical protein, intron |
rs482329* | C/G | 1 | 232883177 | 3/18 | 0.61 | 1.60 | 5.5×10−6 | IRF2BP2, interferon regulatory factor 2 binding protein 2, 72 kb downstream |
rs3848198* | C/T | 15 | 78426619 | 2/4 | 0.38 | 1.81 | 9.8×10−6 | ARNT2, Aryl hydrocarbon receptor nuclear translocator 2; hypoxia associated transcription factor, 57 kb upstream |
rs6565373* | T/C | 16 | 86817543 | 0/1 | 0.59 | 0.32 | 9.8×10−6 | BANP, BTG3 associated nuclear protein isoform a; negative regulator of p53 transcription, 149 kb downstream |
*imputed; #SNPs at P<10−4 indicates the number of SNPs at P<10−4 within +/−150 kb of the top SNP that were either directly genotyped or imputed (genotyped/imputed).