Table 5. Subgroups of hospitalized older patients where different frailty indexes showed a significant different predictive discriminatory power for one-year all-cause mortality.^* .

	Frailty index	AUC	SE	95%	Contrast p-value
					1 vs 2	1 vs 3	1 vs 4
	1 – MPI	0.7086	0.0199	0.67–0.75
ADL 6-5	2 – FI-SOF	0.6553	0.0210	0.61–0.70	0.0007	0.0004	0.0015
(N = 714)	3 - FI-CD	0.6581	0.0209	0.62–0.70
	4 - FI-CGA	0.6667	0.0208	0.63–0.71
	1 – MPI	0.7277	0.0169	0.69–0.76
IADL 8-6	2 – FI-SOF	0.6569	0.0181	0.62–0.69	<0.0001	<0.0001	0.0003
(N = 1038)	3 - FI-CD	0.6820	0.0176	0.65–0.72
	4 - FI-CGA	0.6897	0.0178	0.65–0.72
	1 – MPI	0.7490	0.0170	0.71–0.78
SPMSQ 0-3	2 – FI-SOF	0.7012	0.0178	0.67–0.74	0.0001	0.0012	0.0007
(N = 1503)	3 - FI-CD	0.7279	0.0175	0.69–0.76
	4 - FI-CGA	0.7237	0.0176	0.69–0.76
	1 – MPI	0.7492	0.0163	0.72–0.78
CIRS≥3	2 – FI-SOF	0.6814	0.0173	0.65–0.71	<0.0001	<0.0001	0.0002
(N = 1257)	3 - FI-CD	0.7202	0.0167	0.69–0.75
	4 - FI-CGA	0.7197	0.0170	0.69–0.75
	1 – MPI	0.7374	0.0218	0.69–0.78
MNA<17	2 – FI-SOF	0.6833	0.0234	0.64–0.73	0.0007	0.0651	0.0669
(N = 534)	3 - FI-CD	0.7164	0.0221	0.67–0.76
	4 - FI-CGA	0.7146	0.0224	0.67–0.76
	1 – MPI	0.7069	0.0306	0.65–0.77
Number of drugs ≥7	2 – FI-SOF	0.6473	0.0321	0.58–0.71	0.0197	0.3952	0.0073
(N = 463)	3 - FI-CD	0.6972	0.0313	0.63–0.76
	4 - FI-CGA	0.6712	0.0317	0.61–0.73

AUC: areas under curve; SE: standard error; CI: confidence interval; ADL: activities of daily living; MPI: Multidimensional Prognostic Index; FI-SOF: Frailty Index derived from the Study of Osteoporotic Fractures; FI-CD: Frailty Index based on cumulative deficits; FI-CGA: Frailty Index based on a Comprehensive Geriatric Assessment; IADL: instrumental activities of daily living; SPMSQ: Short Portable Mental Status Questionnaire; CIRS: Cumulative Illness Rating Scale;

MNA: Mini Nutritional Assessment.

*AUCs were assessed by crude and adjusted logistic regression models, accounting for clustering due to centre effect.