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. 2012 Jan 11;7(1):e29615. doi: 10.1371/journal.pone.0029615

Figure 2. Prevention studies with Cmpd-1 and its effect on primary tumor growth in the MDA-MB-231 human breast cancer xenograft model.

Figure 2

(A) Three groups of mice inoculated with cells at day 0 were treated with vehicle (n = 10) or either of the low dose (25 mg/kg twice daily; n = 10) or two-tier (50 mg/kg for initial 10 days and then reduced to low dose; n = 10) Cmpd-1 regimens from day 2 until the end point of the experiment. There was a significant dose-dependent effect of Cmpd-1 on the inhibition of primary tumor growth (vehicle vs. low dose p = 0.0018; vehicle vs. two-tier p<0.0001; ANOVA and Bonferroni post-test). Tumor measurements plotted are expressed as the mean ± S.E.M. (B) Mice treated with low or two-tier Cmpd-1 regimen showed prolonged survival compared to vehicle control (p = 0.0066 and p<0.0001, respectively; Kaplan-Meier survival).