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. 2012 Jan 11;7(1):e29661. doi: 10.1371/journal.pone.0029661

Figure 2. In vivo effect of different concentrations of beta-amyloid on the nicotine-induced overflow of hippocampal neurotransmitters.

Figure 2

Effect of beta-amyloid (Aβ)1–40 (100 nM–10 µM) on 50 mM nicotine (Nic)-induced overflow of GABA (A), glutamate (Glu, B) and aspartate (Asp, C). *p<0.05, **p<0.01, ***p<0.001 vs. Nic (One-way ANOVA followed by Dunnett's Multiple Comparison Test). Data are expressed as mean ± SEM of 4–15 individual rats for each experimental group. Insets show the time course of 50 mM Nic-induced release of GABA (A inset), Glu (B inset) and Asp (C inset). *p<0.05, **p<0.01 vs. basal release (One-way ANOVA followed by Bonferroni post hoc test). Data are expressed as mean ± SEM of 13–15 individual rats.