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. 2012 Jan 11;7(1):e30052. doi: 10.1371/journal.pone.0030052

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Mosco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The leading segments containing a C-terminal thioester, QVF-cHH4-38, QVdF-cHH4-38, pEVdF-cHH4-38, and the cHH39-72 following segment with a free N-terminal cysteine were synthesized by SPPS. The NCL reaction between the leading and following segments returned the full length 72mer cHH isomers, which were further subjected to oxidative folding to obtain the folded peptides.