Skip to main content
. 2012 Jan 11;7(1):e30052. doi: 10.1371/journal.pone.0030052

Figure 3. Time course of the induced glycemia after injection of the synthetic and wild type cHHs.

Figure 3

a) Time course of hemolymph glycemia after injection of 1.7 pmol/g live weight of D-cHH. The maximum peak of 95.4±8.1 mg/dL glucose is reached after 4 h, high values lasting at 8 h (76±12.1 mg/dL), when the maximum values were also recorded, and the glycemia returning to its nearby basal level, 8.9±1 mg/dL, after 24 h. N = 20. b) Time course of hemolymph glycemia after injection of 1.7 pmol/g live weight of L-cHH. L-cHH induced a slower hyperglycemic response with the maximum peak of 52±6.5 mg/dL glucose after 2 h, and the glycemia returning to its nearby basal level, 5.5±0.4 mg/dL, after 8 h. N = 16. c) Time course of hemolymph glycemia after injection of 1.7 pmol/g live weight of Glp-D-cHH. The time course of Glp-D-cHH shows the stronger hyperglycemic response of 96.1±5.6 mg/dL glucose after 4 h, high values lasting at 8 h (62.9±11.8 mg/dL) and the glycemia returning to its basal level, 2.9±0.5 mg/dL, after 24 h. N = 9. d) Time course of hemolymph glycemia after injection of 1.7 pmol/g live weight of SG-cHH. The hyperglycemic time course after the injection of 1.7 pmol/g live weight of purified SG-cHH was comparable to that of synthetic D-cHH and Glp-D-cHH peptides, but the maximum (44±4.5 mg/dL) was reached after 2 h and the glycemia returning to its basal level, 5±1.1 mg/dL after 24 h. N = 9.