Figure 4. Boxplots of the maximum glucose values recorded for the synthetic and native peptides.

Both D-cHH and Glp-D-cHH induced a strong hyperglycemia with a mean peak glucose concentration of, respectively, 100.5±9.3 and 98.7±6 mg/dL, while the hyperglycemic effect of GS-cHH and of L-cHH was lower, with a mean of max glycemia of 52.7±9.4 mg/dL and of 52.4±6.4 mg/dL respectively.