Table 2. Univariate analysis of SNP with significant effects.
| Pathway | Gene | Polymorphism (SNP ID) | Biological Effect | Type of variation | Odds Ratio (95% CI) | ||||
| Controls/Atleast one in UADT/TRC outside UADT | At least one in UADT | P value | TRC outside UADT | P value | |||||
| Xenobiotic metabolism | MPO | G−463 APromoter region(rs 2333227) | Decreased expression and detoxification | GG | 141/70/7 | - | - | ||
| GA | 45/34/6 | 1.52(0.87–2.67) | 0.131 | 2.686(0.752–9.506) | 0.100 | ||||
| AA | 10/9/4 | 1.81(0.64–5.104) | 0.218 | *8.06(1.639–38.837) | 0.008 | ||||
| GA+AA | 55/43/10 | 1.58(0.94–2.65) | 0.076 | *3.66(1.207–11.328) | 0.013 | ||||
| SULT1A1 | Arg213His(rs9282861) | G>A, Decreased enzyme activity, thermostability | Arg/Arg | 132/60/4 | - | - | |||
| Arg/His | 60/43/13 | 1.58(0.93–2.67) | 0.075 | *7.15(2.053–27.244) | <0.001 | ||||
| His/His | 2/6/0 | *6.6(1.16–48.85) | 0.017 | 0(0–199.144) | 1.000 | ||||
| Arg/His+His/His | 62/49/13 | *1.74(1.07–2.82) | 0.026 | *6.92(1.99–26.336) | <0.001 | ||||
| mEH | Tyr113His(rs1051740) | Decreased detoxification | Tyr/Tyr | 78/25/6 | - | - | |||
| Tyr/His | 95/53/6 | 1.74(0.96–3.18) | 0.054 | 0.82(0.223–3.019) | 0.772 | ||||
| His/His | 22/18/3 | *2.55(1.11–5.92) | 0.024 | 1.77(0.319–8.970) | 0.426 | ||||
| Tyr/His+His/His | 117/71/9 | *1.89(1.07–3.365) | 0.020 | 1.00(0.310–3.314) | 1.000 | ||||
| DNA Repair | hOGG1 | Ser326Cys(rs1052133 | Altered localization | Ser/Ser | 114/49/7 | - | - | ||
| Ser/Cys | 62/51/7 | *1.91(1.13–3.25) | 0.011 | 1.84(0.548–6.170) | 0.387 | ||||
| Cys/Cys | 14/8/3 | 1.33(0.47–3.66) | 0.624 | 3.49(0.628–17.735) | 0.108 | ||||
| Ser/Cys+Cys/Cys | 76/59/10 | *1.81(1.09–3.00) | 0.016 | 2.14(0.712–6.572) | 0.198 | ||||
| XRCC1 | Arg280His(rs25489) | Defective localization, decreased repair | Arg/Arg | 157/80/14 | - | - | |||
| Arg/His | 33/30/2 | 1.78(0.98–3.25) | 0.055 | 0.680(0.101–3.371) | 1.000 | ||||
| His/His | 4/4/1 | 1.96(0.40–9.63) | 0.451 | 2.804(0.11–30.328) | 0.363 | ||||
| Arg/His+His/His | 37/34/3 | *1.80(1.02–3.20). | 0.036 | 0.91(0.196–3.632) | 1.000 | ||||
| BRCA2 | Asn372His(rs144848) | Reduced DNA repair | Asn/Asn | 81/30/5 | - | - | |||
| Asn/His | 70/50/6 | *1.93(1.07–3.49) | 0.027 | 1.389(0.355–5.529) | 0.757 | ||||
| His/His | 35/14/4 | 1.08(0.48–2.43) | 0.850 | 1.851(0.388–8.608) | 0.459 | ||||
| Asn/His+His/His | 105/64/10 | 1.65(0.95–2.870) | 0.070 | 1.543(0.461–5.424) | 0.590 | ||||
| Cell Cycle regulation | Cyclin D1 | A 870 GSplice site(rs 603965) | Nuclear accumulation of protein | GG | 67/33/11 | ||||
| GA | 93/55/4 | 1.20(0.68–2.12) | 0.589 | *0.262(0.067–0.943) | 0.028 | ||||
| AA | 45/27/2 | 1.22(0.62–2.41) | 0.627 | 0.271(0.039–1.392) | 0.129 | ||||
| GA+AA | 138/82/6 | 1.21(0.71–2.05) | 0.530 | *0.265(0.083–0.817) | 0.015 | ||||