Table 5. Methylation status of CpG dinucleotides in vav1 promoter in tissues of different histological origin*.
Position | Colon | Pancreas | Stomach | Lymph | Liver | Muscle | Lung | Brain |
−247 | 15 | 83 | 41 | 0 | 46 | 33 | 40 | 63 |
−244 | 7 | 96 | 42 | 0 | 31 | 20 | 40 | 63 |
−156 | 12 | 74 | 19 | 0 | 31 | 13 | 50 | 75 |
−148 | 8 | 100 | 59 | 0 | 38 | 33 | 50 | 94 |
−114 | 4 | 83 | 30 | 0 | 15 | 13 | 50 | 57 |
−71 | 4 | 48 | 24 | 0 | 18 | 21 | 22 | 54 |
−34 | 4 | 57 | 21 | 0 | 18 | 7 | 30 | 46 |
+10 | 8 | 77 | 24 | 0 | 27 | 7 | 33 | 71 |
+21 | 4 | 82 | 13 | 0 | 0 | 0 | 44 | 71 |
+34 | 4 | 82 | 39 | 0 | 27 | 14 | 38 | 86 |
+38 | 15 | 82 | 27 | 0 | 45 | 21 | 38 | 93 |
N | 27 | 24 | 34 | 9 | 13 | 15 | 10 | 16 |
*Percent of methylation on each CpG site was evaluated by bisulfite sequencing. Position refers to that of the CpG dinucleotide relatively to transcription start site (Fig. 1), and N refers to number of sequenced clones.