Figure 1. Overview of the model.
A: The model of the EGFR signaling pathway contains 4 sub-pathways: MAPK pathway, PI3K-AKT pathway, Ca2+ signaling pathway, PAK signaling pathway. B, C are parts of the model network visualized by PyBioS. B: The mRNA BAD-1 is produced by the transcription reaction (1) of gene BAD and also takes part in decay reaction (2) and translation-reaction (3), which produces the protein BAD-1 (cytoplasm). The protein BAD-1 takes part in further three reactions that are the decay-reaction (4), phosphorylation reaction (5) and dephosphorylation reaction (6). The phosphorylated protein P-AKT (plasma membrane) catalyzes the phosphorylation reaction, in which protein BAD-1 is phosphorylated into P-BAD-1. Afterwards, the protein P-BAD-1 is then dephosphorylated; C: shows a simplified miRNA biogenesis, target recognition and competitive anti-miRNA effect. (1) miRNA-gene transcription; (2) miRNA translocation (from nucleus into cytoplasm); (3) miRNA-binding-target reaction; (4) miRNA binds to the miRNA inhibitor.