Table 2.
Enriched GO terms in each module.
| Module | GO ID | p-value | GO description | CHD genes in this module and with this GO term | FDR |
|---|---|---|---|---|---|
| M1 | GO:0019219 | 8.00E-10 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | GATA6 | 1.90E-07 |
| GO:0051171 | 1.10E-09 | regulation of nitrogen compound metabolic process | GATA6 | 2.70E-07 | |
| GO:0051716 | 4.00E-08 | cellular response to stimulus | GATA6 | 9.70E-06 | |
| GO:0045941 | 3.20E-07 | positive regulation of transcription | GATA6 | 7.80E-05 | |
| M3 | GO:0007178 | 7.30E-34 | transmembrane receptor protein serine/threonine kinase signaling pathway | ACVR2B | 2.70E-31 |
| GO:0007179 | 3.70E-23 | Transforming growth factor beta receptor signaling pathway | 1.40E-20 | ||
| GO:0032925 | 1.70E-12 | regulation of activin receptor signaling pathway | ACVR2B | 6.60E-10 | |
| GO:0045597 | 1.10E-09 | positive regulation of cell differentiation | ACVR2B | 4.40E-07 | |
| GO:0051239 | 5.60E-09 | regulation of multicellular organismal process | ACVR2B | 2.10E-06 | |
| GO:0010646 | 1.60E-08 | regulation of cell communication | ACVR2B | 6.40E-06 | |
| M4 | GO:0006468 | 1.20E-04 | protein amino acid phosphorylation | 5.80E-03 | |
| M5 | GO:0006259 | 7.60E-05 | DNA metabolic process | 1.78E-02 | |
| M6 | GO:0045941 | 4.50E-06 | positive regulation of transcription | CITED2 | 5.90E-04 |
| GO:0051254 | 9.80E-06 | positive regulation of RNA metabolic process | CITED2 | 1.20E-03 | |
| GO:0045935 | 1.00E-05 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | CITED2 | 1.30E-03 | |
| M7 | GO:0035556 | 2.20E-04 | intracellular signal transduction | FLNA | 2.52E-02 |
| M8 | GO:0006936 | 1.90E-08 | muscle contraction | MYBPC3 | 3.00E-06 |
| GO:0003008 | 1.80E-06 | system process | MYBPC3 | 2.90E-04 | |
| GO:0007010 | 8.20E-06 | cytoskeleton organization | 1.30E-03 | ||
| GO:0030036 | 8.10E-05 | Actin cytoskeleton organization | 1.31E-02 | ||
| M9 | GO:0007154 | 9.40E-06 | cell communication | GATA4, TBX5 | 1.40E-03 |
| GO:0048545 | 7.50E-05 | response to steroid hormone stimulus | GATA4 | 1.15E-02 | |
| GO:0006629 | 2.30E-04 | lipid metabolic process | 3.57E-02 | ||
| M10 | GO:0022607 | 5.10E-06 | cellular component assembly | ACTC1 | 7.30E-04 |
| GO:0009653 | 9.30E-05 | anatomical structure morphogenesis | ACTC1 | 0.0132 | |
| M11 | GO:0031334 | 2.20E-04 | positive regulation of protein complex assembly | NKX2-5, SRF | 4.42E-02 |
| M12 | GO:0043066 | 2.20E-12 | negative regulation of apoptosis | NOTCH1 | 6.20E-10 |
| GO:0045595 | 1.90E-10 | regulation of cell differentiation | JAG1, NOTCH1 | 5.50E-08 | |
| GO:0051093 | 1.90E-09 | negative regulation of developmental process | JAG1, NOTCH1 | 5.40E-07 | |
| GO:0045596 | 9.70E-09 | negative regulation of cell differentiation | JAG1, NOTCH1 | 2.70E-06 | |
| GO:0007219 | 7.30E-08 | Notch signaling pathway | JAG1, NOTCH1 | 2.00E-05 | |
CHD genes participate in most of the top enriched GO processes in each module and the function of a module is very similar to those of the putative disease genes in it. Only GO terms with FDR<0.05 are shown below.