Table 1.
Current-smoker lung cancer patients with mtDNA and KRAS/EGFR alterations
| Patient ID1 | Age/Sex | Ethnicity2 | Primary site3 | Stage | Number of mtDNA mutation | MtDNA content4 | KRAS/EGFR mutation5 |
|---|---|---|---|---|---|---|---|
| 07L66 | 74/F | C | RUL | IA | 0 | SI | KRAS |
| 07L51 | 53/F | C | LLL | IA | 0 | NC | KRAS |
| 07L5 | 64/F | c | RUL | IB | 0 | NC | KRAS |
| 07L36 | 69/F | A1 | LLL | IB | 0 | NC | NM |
| 07L31 | 47/F | A | RUL | IA | 0 | NC | NM |
| 07L25 | 72/F | C | LUL | IB | 0 | NC | KRAS |
| 06L57 | 53/F | C | N | IIIA | 0 | SI | KRAS |
| 06L54 | 73/M | C | RML | IA | 0 | SI | NM |
| 06L46 | 73/F | C | RUL | IB | 0 | NC | KRAS |
| 06L3 | 67/F | C | LUL | IIB | 0 | NC | NM |
| 06L20 | 70/F | C | RML | IB | 0 | SI | KRAS |
| 06L14 | 57/F | C | N | IIB | 0 | SI | KRAS |
| 06L11 | 67/F | C | N | IA | 0 | NC | KRAS |
| 06L10 | 72/F | C | RLL | IB | 0 | NC | NM |
| 05L19 | 68/F | C | RUL | IV | 0 | SI | NM |
| 0003030 | 68/F | C | RLL | N | 0 | SI | KRAS |
| 0003024 | 63/M | C | RUL | IIIA | 0 | SI | KRAS |
| 0003023 | 74/M | C | LUL | N | 0 | NC | NM |
| 0003022 | 73/M | C | RUL | N | 0 | NC | NM |
| 0003014 | 69/F | C | RUL | N | 0 | NC | KRAS |
| 0003012 | 58/F | C | LUL | N | 0 | SI | NM |
| 0003003 | 61/F | C | LLL | N | 0 | SI | KRAS |
| 07L21 | 67/M | C | RLL | IB | 1 | NC | KRAS |
| 07L32 | 71/F | C | LUL | IIB | 1 | SI | KRAS |
| 06L50 | 73/F | C | LUL | IA | 1 | NC | KRAS |
| 05L9 | 71/F | C | LLL | IA | 1 | NC | KRAS |
| 0003021 | 66/M | C | RUL | - | 1 | SI | NM |
| 0003013 | 64/F | C | RUL | - | 1 | NC | KRAS |
| 05L43 | 64/F | C | LUL | IB | 3 | NC | KRAS |
| 05L32 | 65/M | C | LUL | IIB | 2 | NC | NM |
1
All except one patient (07L36, large cell carcinoma) were adenocarcinoma.
2
Caucasian, A: Asian, AI: American Indian or Alaska;
3
RUL: Right upper lobe, RML: Right middle lobe, RLL: Right lower lobe, LUL: Left upper lobe, LLL: Left lower lobe;
4
MtDNA content was quantitatively determined by Q-PCR (in triplicate) using mitochondria encoded COX-I and nuclear encoded Beta-actin (control) gene. SI: Significant Increase; NC: No significant change in mtDNA content.
5
KRAS/EGFR mutation was examined by sequencing the exon 2 of KRAS and exon 19 and 21 of EGFR; KRAS: KRAS mutation present; NM: No mutation detected in KRAS or EGFR gene.