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. Author manuscript; available in PMC: 2013 Feb 25.
Published in final edited form as: Toxicol Lett. 2011 Nov 30;209(1):58–66. doi: 10.1016/j.toxlet.2011.11.021

Fig. 6. Measurement of (+)-anti-trans-B[a]PDE-dGuo in H358 cells after shMRP4 with (±)-B[a]PDE treatment.

Fig. 6

(A) H358 WT and H358 cells transduced with scramble vector were treated with 2 μM (±)-anti-trans-B[a]PDE. There was no difference in DNA-adduct formation. (B) H358 WT and H358 cells transduced with shMRP4 were also treated with 2 μM (±)-B[a]PDE with and without 10 nM TCDD pretreatment for 24 h. (+)-anti-trans-B[a]PDE-dGuo adducts were quantified by LC-SRM/MS and normalized by total DNA. Plots show means and standard deviations, (*) indicates p=0.014 compared to control and (**) indicates p=0.14 compared to control; n = 3 for each treatment.