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. 2011 Dec 1;6(12):1413–1424. doi: 10.4161/epi.6.12.18271

Figure 2.

Figure 2

Drug induced expression levels of global RASSF1 transcripts and A isoform of RASSF1 gene in breast cancer cell lines. (A) Expression levels in untreated cell lines and after treatment with trichostatin A (TSA). Only two cell lines, Hs 578T and MDA-MB-415, expressed the A isoform of RASSF1 gene. As expected, the TSA treatment alone did not affect DNA methylation and as a result the expression levels of this isoform. (B) The treatment with 5-Aza-dC, isolated or combined with TSA, resulted in the reactivation of A isoform of RASSF1 gene. Gene expression levels were normalized to GAPDH gene. Error bars indicate standard deviation from duplicates.