Table 3.
Co-occurring gene ontology results for the 41 experiment-wide significant genes in the discovery cohort
| Annotations | GO term | Corrected p value* | Genes |
| Inner ear development | GO:0048839 | 2.78 × 10−5 | 3GLI3, TGFB3, DUOX2 |
| Female pregnancy | GO:0007565 | 5.66 × 10−4 | TGFB3, CRHBP, OXT |
| Response to estradiol stimulus | GO:0032355 | 5.86 × 10−4 | ESR1, OXT, CASP8 |
| Heart development | GO:0007507 | 0.0022 | CASP8, GLI3, OXT |
| In utero embryonic development | GO:0001701 | 0.0027 | TGFB3, GLI3, MBNL1 |
| Blood coagulation and platelet activation | GO:0007596 and GO:0030168 | 0.0057 | TGFB3, GP1BB, GP9 |
| Signal transduction | GO:0007165 | 0.0056 | ESR1, FAM13A1, CRHBP, AVP, PIK3CD, OXT |
| DNA-dependent transcription | GO:0006351 | 0.0076 | GLI3, TP73L, ESR1, SLC30A9 |
| Positive regulation of transcription | GO:0045944 | 0.011 | TGFB3, GLI3, TP73L |
| Negative regulation of transcription from RNA polymerase II promoter | GO:0000122 | 0.013 | GLI3, TP73L, PER2 |
| Positive regulation of transcription from RNA polymerase II | GO:0045944 | 0.022 | TGFB3, GLI3, TP73L |
| Cell adhesion | GO:0007155 | 0.033 | GP1BB, GP9, LAMB2 |
Gene names in bold associated with GA in the replication cohort.
*
p values indicate the significance between the number of genes differentially methylated in this analysis and the total number of genes in each annotated biological process.