Table 1.

Painful skin tumors/malformations

Disease	Age	Sex	Common sites	Clinical findings	Histology
Angioleiomyoma	Fourth to sixth decades of life	Women > Men	Lower extremities	Subcutaneous nodule	Encapsulated lesion containing numerous veins with muscular walls (S**)
Angiolipoma	Fourth to sixth decades of life	Men > Women	Forearms	Subcutaneous nodule	Encapsulated lesion containing mature adipose tissue and blood vessels (S)
Eccrine angiomatous hamrtoma	Childhood	Women > Men	Extremities	Angiomatous nodule or red to violaceous plaque	Proliferation of eccrine glands and blood vessels (D***)
Eccrine spiradenoma	Second to fourth decades of life	Men = Women	Head, upper trunk	Intradermal nodule	Sharply demarcated lobules composed of two types of tumor cells ; undifferentiated cells with small, dark nuclei at the periphery and differentiating cells with large, pale nuclei in the center (D)
Glomus tumor	Fourth to sixth decades of life	Women > Men	Extremities, especially in the nail bed	Purple nodule	Encapsulated lesion containing vascular lumina and glomus cells (D)
Granular cell tumor	Fourth to sixth decades of life	Women > Men	Any part of the skin	Raised, firm nodule	A nested growth of large tumor cells with a pale cytoplasm filled with numerous fine granules (D)
Neurilemmoma	Third to fourth decades of life	Men = Women	Head and extremities	Subcutaneous nodule	Sharply demarcated lobules in the dermis. They are composed of two types of tumor cells; cells with small, dark nuclei at the periphery and cells with large, pale nuclei in the center (S)
Piloleiomyoma	Fourth to sixth decades of life	Men > Women	Head, upper extremities	Intradermal nodule	Interlacing bundles of smooth muscle fiberes (D)
Traumatic neuroma	Adult	ND*	Stump after amputation	Firm subcutaneous nodule	Sharply demarcated bundles of peripheral nerves (D)

^*ND, information is lacking.

^**S, main lesion is located in the subcutaneous tissue.

^***D, main lesion is located in the dermis.