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(A) Co-RNA-FISH using probes against MALAT1 (a, green) and Neat1 (a′, red) reveals distribution of MALAT1 and Neat1 RNA in nuclear speckles and paraspeckles respectively. (B) Depletion of MALAT1 (MALAT1-AS) in HeLa cells results in nuclear fragmentation. Note that the fragmented nuclei contain nuclear pores (green) and nuclear lamina (red). DNA is counterstained with DAPI. The bar represents 5 µm.
