Tab 1: Survivin for breast cancer diagnosis and detection.

Year/first author/reference	Alone or combined	Assay	Collection	Conclusions
2002/Nasu S (63)	alone	RT-PCR 37/41 (90.2%)	specimen	a useful diagnostic marker for breast cancer.
2002/Izawa A (64)	with c-erbB2 and PLU-1	RT-PCR27/39 (69.2%)	specimen	useful as a marker for diagnosis
2006/Yie SM (60)	alone	RT-PCR ELISA	PB	PPV in vessel infiltration, histological grade, tumor size, nodal status, ER/PgR status, Her-2 status and clinical stages
2006/Chen CC (61)	with PTTG1, UbcH10 and TK1	membrane array technique	PB	PPV in tumor size, histologic grade, lymph node metastasis and TNM stage
2006/Guney N (62)	alone	EIA and ELISA	Serum and urine	serum survivin level could be a sensitive marker for detecting metastases in lymph nodes
2009/Shen C (65)	with hTERT and hMAM	real-time q PCR	PB	PPV in TNM stage, and lymph node metastasis

PPV: positive predictive value, NPV: negative predictive value, (q) RT-PCR, (quantitative) reverse transcriptase polymerase chain reaction, ELISA, enzyme linked immunosorbent assay, PB, peripheral blood.